Two dimensional fermions in three dimensional YM

Dirac fermions in the fundamental representation of SU(N) live on the surface of a cylinder embedded in $R^3$ and interact with a three dimensional SU(N) Yang Mills vector potential preserving a global chiral symmetry at finite $N$. As the circumference of the cylinder is varied from small to large, the chiral symmetry gets spontaneously broken in the infinite $N$ limit at a typical bulk scale. Replacing three dimensional YM by four dimensional YM introduces non-trivial renormalization effects.Comment: 21 pages, 7 figures, 5 table

Luminosity Function of the Perigalactocentric Region

We present H and K photometry of 42,000 stars in an area of 250 arcmin$^{2}$ centered on the Galactic center. We use the photometry to construct a dereddened K band luminosity function (LF) for this region, excluding the excessively crowded inner 2' of the Galaxy. This LF is intermediate between the LF of Baade's window and the LF of inner 2' of the Galactic center. We speculate that the bright stars in this region have an age which is intermediate between the starburst population in the Galactic center and the old bulge population. We present the coordinates and mags for 16 stars with K_{0} < 5 for spectroscopic follow up.Comment: 25 pages. Tarred, gzipped and uuencoded. Includes LaTex source file, Figures 3 to 9 and 5 Tables. Figures 1 and 2 are available at ftp://bessel.mps.ohio-state.edu/pub/vijay . Submitted to Ap

Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation.

Actin filament assembly by the actin-related protein (Arp) 2/3 complex is necessary to build many cellular structures, including lamellipodia at the leading edge of motile cells and phagocytic cups, and to move endosomes and intracellular pathogens. The crucial role of the Arp2/3 complex in cellular processes requires precise spatiotemporal regulation of its activity. While binding of nucleation-promoting factors (NPFs) has long been considered essential to Arp2/3 complex activity, we recently showed that phosphorylation of the Arp2 subunit is also necessary for Arp2/3 complex activation. Using molecular dynamics simulations and biochemical assays with recombinant Arp2/3 complex, we now show how phosphorylation of Arp2 induces conformational changes permitting activation. The simulations suggest that phosphorylation causes reorientation of Arp2 relative to Arp3 by destabilizing a network of salt-bridge interactions at the interface of the Arp2, Arp3, and ARPC4 subunits. Simulations also suggest a gain-of-function ARPC4 mutant that we show experimentally to have substantial activity in the absence of NPFs. We propose a model in which a network of auto-inhibitory salt-bridge interactions holds the Arp2 subunit in an inactive orientation. These auto-inhibitory interactions are destabilized upon phosphorylation of Arp2, allowing Arp2 to reorient to an activation-competent state

Domain-wall fermions with U(1)U(1) dynamical gauge fields

We have carried out a numerical simulation of a domain-wall model in $(2+1)$-dimensions, in the presence of a dynamical gauge field only in an extra dimension, corresponding to the weak coupling limit of a ( 2-dimensional ) physical gauge coupling. Using a quenched approximation we have investigated this model at $\beta_{s} ( = 1 / g^{2}_{s} ) =$ 0.5 ( ``symmetric'' phase), 1.0, and 5.0 (``broken'' phase), where $g_s$ is the gauge coupling constant of the extra dimension. We have found that there exists a critical value of a domain-wall mass $m_{0}^{c}$ which separates a region with a fermionic zero mode on the domain-wall from the one without it, in both symmetric and broken phases. This result suggests that the domain-wall method may work for the construction of lattice chiral gauge theories.Comment: 27 pages (11 figures), latex (epsf style-file needed

Probing the Region of Massless Quarks in Quenched Lattice QCD using Wilson Fermions

We study the spectrum of $H(m)=\gamma_5 W(-m)$ with $W(m)$ being the Wilson-Dirac operator on the lattice with bare mass equal to $m$. The background gauge fields are generated using the SU(3) Wilson action at $\beta=5.7$ on an $8^3\times 16$ lattice. We find evidence that the spectrum of $H(m)$ is gapless for $1.02 < m < 2.0$, implying that the physical quark is massless in this whole region.Comment: 22 pages, LaTeX file, uses elsart.sty, includes 11 figures A typographical error in one reference has been fixe

Numerical computation of the beta function of large N SU(N) gauge theory coupled to an adjoint Dirac fermion

We use a single site lattice in four dimensions to study the scaling of large N Yang-Mills field coupled to a single massless Dirac fermion in the adjoint representation. We use the location of the strong to weak coupling transition defined through the eigenvalues of the folded Wilson loop operator to set a scale. We do not observe perturbative scaling in the region studied in this paper. Instead, we observe that the scale changes very slowly with the bare coupling. The lowest eigenvalue of the overlap Dirac operator is another scale that shows similar behavior as a function of the lattice coupling. We speculate that this behavior is due to the beta function appoaching close to a zero.Comment: 16 pages, 9 figures, revised version DOES NOT match the published version in Physical Review

Chiral Symmetry Restoration in the Schwinger Model with Domain Wall Fermions

Domain Wall Fermions utilize an extra space time dimension to provide a method for restoring the regularization induced chiral symmetry breaking in lattice vector gauge theories even at finite lattice spacing. The breaking is restored at an exponential rate as the size of the extra dimension increases. Before this method can be used in dynamical simulations of lattice QCD, the dependence of the restoration rate to the other parameters of the theory and, in particular, the lattice spacing must be investigated. In this paper such an investigation is carried out in the context of the two flavor lattice Schwinger model.Comment: LaTeX, 37 pages including 18 figures. Added comments regarding power law fitting in sect 7. Also, few changes were made to elucidate the content in sect. 5.1 and 5.3. To appear in Phys. Rev.

In silico estimates of the free energy rates in growing tumor spheroids

The physics of solid tumor growth can be considered at three distinct size scales: the tumor scale, the cell-extracellular matrix (ECM) scale and the sub-cellular scale. In this paper we consider the tumor scale in the interest of eventually developing a system-level understanding of the progression of cancer. At this scale, cell populations and chemical species are best treated as concentration fields that vary with time and space. The cells have chemo-mechanical interactions with each other and with the ECM, consume glucose and oxygen that are transported through the tumor, and create chemical byproducts. We present a continuum mathematical model for the biochemical dynamics and mechanics that govern tumor growth. The biochemical dynamics and mechanics also engender free energy changes that serve as universal measures for comparison of these processes. Within our mathematical framework we therefore consider the free energy inequality, which arises from the first and second laws of thermodynamics. With the model we compute preliminary estimates of the free energy rates of a growing tumor in its pre-vascular stage by using currently available data from single cells and multicellular tumor spheroids.Comment: 27 pages with 5 figures and 2 tables. Figures and tables appear at the end of the pape

Perturbative study for domain-wall fermions in 4+1 dimensions

We investigate a U(1) chiral gauge model in 4+1 dimensions formulated on the lattice via the domain-wall method. We calculate an effective action for smooth background gauge fields at a fermion one loop level. From this calculation we discuss properties of the resulting 4 dimensional theory, such as gauge invariance of 2 point functions, gauge anomalies and an anomaly in the fermion number current.Comment: 39 pages incl. 9 figures, REVTeX+epsf, uuencoded Z-compressed .tar fil